20 MIN READ

Understanding Cereal Herbicide Modes of Action

November 18, 2021

The mode of action is the overall manner in which a herbicide affects a plant at the tissue or cellular level. Herbicides with the same mode of action will have the same translocation (movement) pattern and produce similar injury symptoms. Understanding target weed types, ideal crop and weed staging, the benefits, and watchouts of each herbicide mode of action can help with deciding which chemical to use and when. Understanding translocation activity can help inform application requirements such as droplet size and water volume. Understanding soil activity and how the herbicide works can help set expectations for when and how long to expect symptoms, when to scout for weed control, and how to identify herbicide symptoms. These are general descriptions and full detail for each herbicide product can be found on the label. Always read and follow label requirements.


Herbicide Resistance Management by Mode of Action


Herbicide resistance is a rising problem of economic significance. Herbicide resistant weed populations continue to develop due to widespread reliance on a small array of common herbicides. When the same herbicide is applied to an area year after year that contains resistant weeds, the susceptible plants die while the resistant ones survive and spread their populations every year. Within a single weed species, there can be resistant and non-resistant (susceptible) populations.

The mode of action classification can be used to understand and manage herbicide resistance. One tool to manage herbicide resistance is to use multiple effective modes of action on the same weed population. This can be done in the same year by tank-mixing or layering multiple modes of action. Additionally, rotating herbicide modes of action from year to year provides another opportunity to manage herbicide resistance. The target weed types for each mode of action provide a quick reference that can be used to help select alternate modes of action with activity on the same weed type.

Any opportunity to use another mode of action for weed control lowers the selection pressure that can be caused by repeatedly using the same mode of action on the same weed population. Herbicide resistance is discussed in detail for Group 1 and Group 2 herbicides though resistant weeds have been found for each herbicide mode of action and management practices described above should be used to reduce selection pressure on any herbicide mode of action.


Click on the herbicide group to learn more

Mode of Action: Acetyl-Coenzyme A Carboxylase (ACCase) inhibitors

Target Weed Types: Grasses

Systemic or contact: Systemic

Soil residual: Little to no residual herbicide activity

Crop staging: Post-emergent

Crop staging varies for each herbicide and can be found on the herbicide label.

Weed staging: Post-emergent

Varies somewhat by product but Group 1 herbicides are most effective when applied to young, actively growing weeds.

How it works: Group 1 herbicides inhibit the first step in the formation of long chain fatty acids which are important for cell membrane formation; they ultimately stop new growth. Group 1 herbicides are slow acting as herbicide is translocated through the plant, accumulating in the growing points (roots and shoots). New growth ceases quickly after herbicide application; however, total plant death may take up to three weeks. Early symptoms can be found at the growing point beginning with streaky chlorosis of young leaves (Figure 1). Leaf sheaths decompose within the whorl turning from chlorotic to necrotic and are easily pulled out as the growing point dies (Figure 2). The ACCase enzyme in broadleaf plants is not sensitive to the herbicide and therefore broadleaf plants are not affected by Group 1 herbicides. Some grasses can metabolize the herbicide quicker and can survive while other grasses die. Group 1 herbicides can be used in the registered cereal crops as these crops are able to metabolize the toxin.

Benefits: Group 1 herbicides provide the opportunity to manage some grassy weeds in wheat and barley with no re-cropping concerns.

Watchouts: Antagonism, crop safety, herbicide resistance

Antagonism: When applied together or in close succession, some broadleaf herbicides can antagonize Group 1 herbicides. Contact herbicides can quickly burn leaf surfaces, inhibiting absorption of the Group 1 herbicide. The enhanced metabolism caused by Growth Regulator (Group 4) herbicides can allow weeds to also metabolize the Group 1 herbicide before it builds to toxic levels. Group 1 herbicides should only be mixed with registered tank-mix partners.

Crop Response: Crop response can be managed by applying Group 1 herbicides within labeled crop stage in good growing conditions with labeled tank-mix partners.



Leaf streaking caused by Group 1 herbicide.. Mode of Action: Acetyl-Coenzyme A Carboxylase (ACCase) inhibitors
Figure 1. Leaf streaking caused by Group 1 herbicide.
Main shoot death at the growing point. Newest leaf appears yellow or brown and easily pulls out of the leaf sheath.
Figure 2. Main shoot death at the growing point. Newest leaf appears yellow or brown and easily pulls out of the leaf sheath.



Herbicide resistance: Weed populations resistant to Group 1 herbicides will require additional management. There are three herbicide families within Group 1; however, when resistance develops in a weed population typically there is a level of resistance to all Group 1 herbicide families.


Mode of Action: Acetolactate synthase (ALS) inhibitors

Target Weed Types: Product specific

Some Group 2 herbicides provide mainly broadleaf weed control. Others provide broadleaf and grassy weed control.

The active ingredients: imazamox, flucarbazone, mesosulfuron, propoxycarbazone, pyroxsulam, and thiencarbazone, provide grassy weed control as well as broadleaf control. The active ingredients: florasulam, thifensulfuron, tribenuron, and metsulfuron provide mainly broadleaf weed control.

Systemic or contact: Systemic

Soil residual: Yes

Residual effects vary for each herbicide; some have season-long residual effects while others have little to no residual effect.

Crop staging: Product specific

Staging varies greatly as some products are applied pre-plant or pre-emerge while other products are foliar applied post-emerge.
Weed staging: Product specific

Some Group 2 herbicides are applied pre-emerge while others are foliar applied.

How it works: Group 2 herbicides inhibit the production of important amino acids. Plants stop growing soon after herbicide uptake and the plant slowly dies. Symptoms may not be noticed with soil applied herbicides because target weeds simply do not emerge, or they may emerge and remain stunted (Figure 3). Plant growth symptoms appear as shortened internodes and stunted roots which may be visible one week after herbicide application. Chlorosis may appear at the growing point (Figure 4). Reddening or purple discoloration is a symptom on both grasses and broadleaves (Figure 5). Broadleaves may also display abnormal growth at the growing point.


Winter wheat stunting following Group 2 pre-plant application. Mode of Action: Acetolactate synthase (ALS) inhibitors.
Figure 3. Winter wheat stunting following Group 2 pre-plant application. Photo courtesy of P. Sikkema, University of Guelph.


Chlorosis of wild oats between rows of wheat following application of Group 2 herbicide. Mode of Action: Acetyl-Coenzyme A Carboxylase (ACCase) inhibitors
Figure 4. Chlorosis of wild oats between rows of wheat following application of Group 2 herbicide. Photo courtesy of Lyndsey Friesen.


Group 2 herbicide activity causing chlorosis and reddening of leaves and necrosis of the growing point on white campion. Mode of Action: Acetolactate synthase (ALS) inhibitors
Figure 5. Group 2 herbicide activity causing chlorosis and reddening of leaves and necrosis of the growing point on white campion.


Benefits: Residual weed control of some Group 2 herbicides, grass and broadleaf weed control of some Group 2 herbicides

Watchouts: Herbicide resistance, re-cropping restrictions, crop injury

Herbicide resistance: Cross resistance, or herbicide-resistance to multiple chemical families within a single mode of action, is common with ALS inhibitors.1 Resistance can happen easily with a minimum of a single amino acid substitution at the herbicide target site. Since the target site of the herbicide is not the same as the target site of the enzyme that the herbicide inhibits, there may not be a fitness penalty to the weed, allowing the resistant weed to proliferate.

Re-cropping restrictions: Re-cropping restrictions are another watch-out for some Group 2 herbicides, depending on the specific herbicide chemistry. Soil residual activity of some Group 2 herbicides can be limiting to crop rotation as sensitive crops may not be grown in following years. Residual soil activity is impacted by the herbicide chemistry, the herbicide family, soil pH, soil temperature, soil moisture, soil texture and organic matter in the soil. Some Group 2 herbicides have longer carryover with a high soil pH while others carryover longer when the soil pH is low. In most cases, warm, moist conditions help break down the herbicide and limit carryover concerns as long as the label re-cropping restrictions are followed. High organic matter and high clay content in soil can cause Group 2 herbicides to bind to the soil, becoming unavailable for plant uptake. In this state, the herbicide is unlikely to cause crop injury, but may persist for an extended period and become problematic if a heavy rainfall washes the herbicide back into soil solution. Low organic matter and low clay content can also result in herbicide injury due to carryover following a dry year. In these soils degradation occurs at a lower rate and less herbicide is adsorbed to the soil, leaving herbicides readily available for plant uptake following a rain.1

Crop injury: Crop injury in the year of herbicide application can be managed by applying Group 2 herbicides in good growing conditions where the crop is actively growing and can quickly metabolize the herbicide.


Mode of Action: Mitotic Inhibitors, Microtubule Inhibitors, Seedling Growth Inhibitors2

Target Weed Types: Annual grasses with some activity on broadleaf weeds

Systemic or contact: Contact

Soil residual: Yes

Most Group 3 herbicides have full season residual benefits.

Crop staging: Pre-plant incorporated
Weed staging: Pre-emerge

Group 3 herbicides are not effective on established weeds.

How it works: Group 3 herbicides are absorbed primarily by roots of emerging seedlings and can also be absorbed by emerging shoots. The herbicide works as a contact herbicide at the point of uptake (roots and shoots) to stop cell division and inhibit new growth. The seedling must germinate before herbicide can be effective. Often, controlled seedlings do not emerge from the soil surface. As seedlings emerge root growth is reduced, and stems may be swollen or brittle (Figure 6).

Benefits: Season-long residual control of target weeds

Watchouts: Application, carryover

Application: These herbicides have specific instructions for application and require incorporation (harrowing at minimum) to prevent break-down by light and loss by volatilization.

Carryover: Application rates must be followed to prevent crop injury or carry-over. Rates are limited by soil organic matter and soil texture.


Short, stubby roots are a symptom of Group 3 herbicide activity. Mode of Action: Mitotic Inhibitors, Microtubule Inhibitors, Seedling Growth Inhibitors
Figure 6. Short, stubby roots are a symptom of Group 3 herbicide activity. Photo courtesy of Rebekah D. Wallace, University of Georgia, Bugwood.org


Mode of Action: Synthetic auxins

Target Weed Types: Annual, winter annual, and biennial broadleaves with some suppression or control of perennial broadleaves and limited activity on grasses

Systemic or contact: Systemic

Soil residual: Some

Length of residual varies by product and rate.

Crop staging: Pre- or post-emerge
Weed staging: Wide range of weed staging depending on weed species and herbicide product

In-crop applications should target young, actively growing annuals. Perennials are best controlled with Group 4 herbicides when applied in the fall at bud stage.

How it works: Group 4 herbicides are taken up by leaves, stems, and roots and translocated to the growing points in roots and shoots where they stimulate uncontrolled cell division and growth. Symptoms on new growth are twisting and curving of petioles and stems and distorted leaves and heads (Figure 7). Plant death is slow.

Benefits: Effective broadleaf weed management in cereal crops.

Watchouts: Re-cropping restrictions, herbicide resistance

Re-cropping restrictions: This can be a concern for some Group 4 herbicides, such as clopyralid, especially in application years with lower-than-average rainfall.

Herbicide resistance: As herbicides are widely used, there are some weeds with Group 4 herbicide resistance.


Cleavers showing leaf cupping and twisting stems following application of Group 4 herbicide. Mode of Action: Synthetic auxins
Figure 7. Cleavers showing leaf cupping and twisting stems following application of Group 4 herbicide. Photo courtesy of Eric Johnson, University of Saskatchewan.

Mode of Action: Fast-acting photosynthesis inhibitors

Target Weed Types: Annual broadleaves

Systemic or contact: Contact

Soil residual: Little to no residual herbicide activity

Crop staging: Post emerge

Can be applied pre-emerge to crop but can only control weeds that have emerged. See herbicide label for specific crop staging.
Weed staging: Small, young weeds

Herbicide must contact the foliage of weeds. See herbicide label for specific weed staging.

How it works: Group 6 herbicides are contact herbicides that are primarily absorbed by plant foliage. They act quickly, inhibiting photosynthesis, resulting in water-soaked lesions that quickly become chlorotic and die within days of application. These herbicides work best when they have contact with the growing point. Following herbicide application, perennial broadleaves can appear burnt off and dead and later regrow from root reserves.

Benefits: Fast-acting annual broadleaf weed control

Watchouts: Coverage, crop injury

Coverage: Thorough coverage is essential for weed control with Group 6 herbicides. Droplet size, water volume, weed size, and crop canopy density can all impact weed control. Smaller droplets can provide more thorough coverage but can also be more prone to particle drift. Follow the label recommendations for appropriate droplet size for the herbicide. Increased water volume on small seedling weeds prior to crop canopy closure are some management practices that can be used to encourage thorough coverage with Group 6 herbicides.

Crop injury: Increased herbicide uptake can result in crop injury. This can be a result of a thin cuticle such as when the crop is young, or when environmental conditions change quickly from cool and wet to hot and humid. Application within two to three days of stressful growing conditions may also result in crop injury (Figure 8).


Group 6 herbicide applied with adverse weather conditions (same-day freezing). Mode of Action: Fast-acting photosynthesis inhibitors
Figure 8. Group 6 herbicide applied with adverse weather conditions (same-day freezing). Photo courtesy of P. Sikkema, University of Guelph.


Mode of Action: Enolpyruvyl Shikimate Phosphate Synthase (EPSPS) Inhibitors

Target Weed Types: Annual, biennial, and perennial grass, sedge, and broadleaf weeds

Systemic or contact: Systemic

Soil residual: No

Crop staging: Pre-emerge, preharvest, or postharvest
Weed staging: Post-emerge

Ideal timing varies by weed. Annual and winter annual weeds can be managed prior to crop emergence. A pre-harvest application is better suited for management of perennial weeds such as Canada thistle, perennial sow thistle, quackgrass, and milkweed. Postharvest applications can also be utilized for weed management.

How it works: Glyphosate, the only Group 9 herbicide, is rapidly absorbed by foliage of target weeds. It is translocated and accumulated in growing points, underground tissues, and immature leaves. Glyphosate inhibits the synthesis of key amino acids needed for protein synthesis. Growth stops soon after herbicide application though additional symptoms may be slower to appear, especially in perennial weeds. Chlorosis of the growing point and new leaves is followed by plant death which may take up to three weeks (Figures 9 and 10).

Benefits: Glyphosate is a broad-spectrum herbicide effective on many weeds.

Watchouts: Application timing, herbicide resistance

Application timing: Glyphosate will kill emerged cereal crops. Apply pre-emerge to the cereal crop. In preharvest applications, crop staging is important as early applications may result in unacceptable herbicide residue in harvested grain.

Herbicide resistance: As herbicides are widely used, there are some weeds with Group 9 herbicide resistance.



Early symptoms of chlorosis and necrosis following glyphosate application.
Figure 9. Early symptoms of chlorosis and necrosis following glyphosate application.


Symptoms of glyphosate application on grassy weeds. Field begins to appear dull green to yellow as chlorosis begins in weeds. Glyphosate application field symptoms fall burndown following wheat.
Figure 10. Symptoms of glyphosate application on grassy weeds. Field begins to appear dull green to yellow as chlorosis begins in weeds.


Mode of Action: Protoporphyrinogen IX oxidase (PPO) inhibitors

Target Weed Types: Primarily broadleaves

Some Group 14 herbicides provide suppression of some annual grasses.

Systemic or contact: Contact

Soil residual: Product specific

Residual can be minimal or last for several weeks.

Crop staging: Preplant, pre-emerge, preharvest

Weed staging: Product specific

Foliar applied herbicides should be applied to small, actively growing weeds. Soil applied herbicides are taken up by weeds prior to emergence.

How it works: Group 14 herbicides are readily absorbed by foliage of emerged plants or by roots of emerging plants. Singlet oxygen radicals are formed due to PPO inhibition. These oxygen radicals destroy cell membranes resulting in loss of chlorophyll, necrosis, and plant death. The first symptoms of herbicide activity are water-soaked lesions followed by bronzing and then necrosis (Figure 11). Symptoms can appear within hours of herbicide application with plant death occurring quickly only a few days later.

Light is required to activate these herbicides. Seedlings may take up the herbicide and then emerge from soil surface before herbicide activity occurs. Banding at the soil line is a good sign that this herbicide activity has occurred and weed seedlings die shortly after emergence.

Benefits: Fast-acting annual broadleaf weed control. Soil residual activity of some Group 14 herbicides provides longer weed control.

Watchouts: Coverage, soil activation, re-cropping restrictions, application timing

Coverage: The foliar applied herbicides require thorough coverage when applied to emerged weeds.

Soil activation: Soil applied herbicides require rainfall for activation.

Re-cropping restrictions: Soil applied herbicides may limit rotational crop options.

Application timing: Group 14 herbicides are preplant, pre-emerge, and preharvest herbicides for cereal crops. In-crop application can cause serious crop injury (Figure 12). Read and follow the label to ensure crop safety.


Water-soaked lesions on redroot pigweed are early symptoms of Group 14 herbicide activity. Mode of Action: Protoporphyrinogen IX oxidase (PPO) inhibitors
Figure 11. Water-soaked lesions on redroot pigweed are early symptoms of Group 14 herbicide activity. Photo courtesy of Eric Johnson, University of Saskatchewan.


Group 14 injury from post-emergent application in small plots of cereal crops (front). Mode of Action: Protoporphyrinogen IX oxidase (PPO) inhibitors
Figure 12. Group 14 injury from post-emergent application in small plots of cereal crops (front). Photo courtesy of P. Sikkema, University of Guelph.

Mode of Action: Very long-chain fatty acid synthesis inhibitors

Target Weed Types: Annual grasses, some small-seeded broadleaves

Target weeds are very specific to the herbicide. Triallate only controls wild oats.

Systemic or contact: Systemic*

*Herbicide can translocate but this in not relevant since the herbicide works at the point of uptake on seedling weeds.

Soil residual: Yes

Crop staging: Preplant, preplant incorporated, pre-emerge
Weed staging: Pre-emerge

How it works:

Group 15 herbicides are absorbed primarily by shoots of emerging seedlings; root uptake is also possible. Very long chain fatty acid inhibition results in disruption of cell membrane formation and cell growth. Seedling plants affected by Group 15 herbicides often fail to emerge or emerge severely deformed or with inhibited root growth (Figure 13). In grassy weeds, the new leaf may appear malformed or fail to unroll (Figure 14). In broadleaf weeds, necrosis may appear on leaf margins and the “drawstring” effect may appear on new leaves (Figure 15).

Benefits: Residual control

Watchouts: Rainfall activation, incorporation, soil properties, application timing

Rainfall activation: These herbicides require rainfall within 10 to 14 days of application for successful activation.

Incorporation: Incorporation requirements vary for Group 15 herbicides.

Soil properties: Risk of crop injury increases when these herbicides are applied on coarse textured soils with low organic matter. Specific information for each herbicide can be found on the herbicide’s label. Residual activity can be reduced over time or with low rates, excessive rainfall, or warm and moist conditions that encourage microbial breakdown of the herbicide.

Application timing: These are preplant and pre-emerge herbicides and are not for use in-crop.


Untreated on left compared to triallate treated wild oats on right.
Figure 13. Untreated on left compared to triallate treated wild oats on right. Photo courtesy of Eric Johnson, University of Saskatchewan.


Malformed leaves of green foxtail as a result of Group 15 herbicide. Mode of Action: Very long-chain fatty acid synthesis inhibitors
Figure 14. Malformed leaves of green foxtail as a result of Group 15 herbicide. Photo courtesy of Eric Johnson, University of Saskatchewan.


Drawstring effect on stinkweed leaf.
Figure 15. Drawstring effect on stinkweed leaf. Photo courtesy of Eric Johnson, University of Saskatchewan.


Mode of Action: Hydroxyphenyl pyruvate dioxygenase (HPPD) inhibitors

Target Weed Types: Annual broadleaves

Some Group 27 herbicides also have activity on grasses or perennial broadleaf weeds.

Systemic or contact: Systemic

Soil residual: Product specific

Currently registered Group 27 herbicides for cereal crops are applied post-emerge with little soil residual benefit.

Crop staging: Product specific

For cereal crops, the Group 27 herbicides currently available are post-emerge herbicides. The crop should be between the 1-leaf stage and flag leaf visible but still rolled.
Weed staging: Product specific

For cereal crops, the Group 27 herbicides currently available are applied in-crop to emerged weeds. Weeds should be young and actively growing.

How it works: Group 27 herbicides are translocated to roots and shoots and symptoms first appear at these growing points. The inhibition of HPPD stops production of carotenoids. The result is severe bleaching of foliage which appears two to three days after herbicide application (Figures 16, 17, and 18). Plant growth is inhibited followed by plant death.

Benefits: Synergy with Group 5 and 6 herbicides on broadleaf weed control, additional mode of action for broadleaf weed control

Watchouts: Residual activity

Residual activity: Following seasons of low rainfall, microbial breakdown of herbicide is limited, and Group 27 herbicides can persist to the following growing season.


Typical bleaching of Group 27 herbicide is very visual in small plots. Mode of Action: Hydroxyphenyl pyruvate dioxygenase (HPPD) inhibitors
Figure 16. Typical bleaching of Group 27 herbicide is very visual in small plots. Photo courtesy of P. Sikkema, University of Guelph.


Bleaching of growing point of kochia caused by Group 27 herbicide. Pyrasulfotole on Kochia. Mode of Action: Hydroxyphenyl pyruvate dioxygenase (HPPD) inhibitors
Figure 17. Bleaching of growing point of kochia caused by Group 27 herbicide.


Bleaching of growing point of Canada thistle caused by Group 27 herbicide. Pyrasulfotole to Canada thistle. Mode of Action: Hydroxyphenyl pyruvate dioxygenase (HPPD) inhibitors
Figure 18. Bleaching of growing point of Canada thistle caused by Group 27 herbicide.


Sources:

1 The Canola Council of Canada. 2019. Dry conditions elevate herbicide carryover risk. Canola Watch February 8, 2019 Issue 2. https://www.canolacouncil.org/canola-watch/2019/02/08/dry-conditions-elevate-herbicide-carryover-risk/

2 Powles, S.B., Yu, Q. 2010. Evolution in action: Plants resistant to herbicides. Annual Review of Plant Biology Vol. 61: 317-347. DOI 10.1146

Sikkema, P., Robinson D., Johnson, E. 2021. Weed science short course. University of Guelph.

Ontario Ministry of Agriculture, Food and Rural Affairs. 2009. Herbicide mode of action categories. Factsheet ISSN 11980712X. http://www.omafra.gov.on.ca/english/crops/facts/00-061.htm

Manitoba Agriculture and Resource Development. 2020. Guide to crop protection 2020.

Herbicide Resistance Action Committee. 2021. HRAC Mode of Action Classification 2021. www.hracglobal.com

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    Performance may vary, from location to location and from year to year, as local growing, soil and weather conditions may vary. Growers should evaluate data from multiple locations and years whenever possible and should consider the impacts of these conditions on the grower’s fields.

    The Bayer Carbon Program described in this material is subject to the current version of the Bayer Carbon-Smart Practices Master Agreement. The information is to aid in the understanding of the Bayer Carbon Program and does not change or modify the Bayer Carbon-Smart Practices Master Agreement in any way.

    The RRXtend Spray App provides forecasts for locations within the contiguous United States. Do not use this app for forecasts outside the contiguous United States. Forecasts are for planning purposes only and are not a substitute for checking actual weather conditions at your location at the time of application and comply with the product label and other legal requirements.

    B.t. products may not yet be registered in all states. Check with your seed brand representative for the registration status in your state.

    Refuge seed may not always contain the DroughtGard® trait. Adament™ 50 WG Fungicide is only registered in California. Roundup Technology® includes glyphosate-based herbicide technologies.

    IMPORTANT IRM INFORMATION: Certain products are sold as RIB Complete® corn blend products, and do not require the planting of a structured refuge except in the Cotton-Growing Area where corn earworm is a significant pest. Products sold without refuge in the bag (non-RIB Complete) require the planting of a structured refuge. See the IRM/Grower Guide for additional information. Always read and follow IRM requirements.

    ONLY USE FORMULATIONS THAT ARE SPECIFICALLY LABELED FOR SUCH USES AND APPROVED FOR SUCH USE IN THE STATE OF APPLICATION. Contact the U.S. EPA and your state pesticide regulatory agency with any questions about the approval status of dicamba herbicide products for in-crop use with products with XtendFlex® Technology.

    ALWAYS READ AND FOLLOW PESTICIDE LABEL DIRECTIONS. It is a violation of federal and state law to use any pesticide product other than in accordance with its labeling. NOT ALL formulations of dicamba or glyphosate are approved for in-crop use with Roundup Ready 2 Xtend® soybeans. NOT ALL formulations of dicamba, glyphosate or glufosinate are approved for in-crop use with products with XtendFlex® Technology.

    Roundup Ready® Technology contains genes that confer tolerance to glyphosate. Roundup Ready® 2 Technology contains genes that confer tolerance to glyphosate. LibertyLink® Technology contains genes that confer tolerance to glufosinate. Roundup Ready® Flex Technology contains genes that confer tolerance to glyphosate. Roundup Ready technology contains genes that confer tolerance to glyphosate, an active ingredient in Roundup® brand agricultural herbicides. Roundup Ready 2 Xtend® soybeans contain genes that confer tolerance to glyphosate and dicamba. Products with XtendFlex® Technology contains genes that confer tolerance to glyphosate, glufosinate and dicamba. Plants that are not tolerant to glyphosate, dicamba, and/or glufosinate may be damaged or killed if exposed to those herbicides. Contact your seed brand dealer or refer to the Bayer Technology Use Guide for recommended weed control programs.

    Insect control technology provided by Vip3A is utilized under license from Syngenta Crop Protection AG. Movento® MPC Insecticide is only registered for use in Florida, Georgia and Alabama. Aeris®, Balance® Flexx, Baythroid® XL, Corvus®, Degree Xtra®, Harness® Xtra 5.6L Herbicide, Harness® Xtra Herbicide, Huskie® Complete, Leverage® 360, and TriVolt™ are restricted use pesticides. Not all products are registered for use in all states and may be subject to use restrictions. The distribution, sale, or use of an unregistered pesticide is a violation of federal and/or state law and is strictly prohibited. Check with your local dealer or representative for the product registration status in your state. Fortenza Advanced™ is an on-seed application of Fortenza® and Rascendo® seed treatments. Agrisure Viptera®, Fortenza Advanced™, Fortenza® and Rascendo® are trademarks of Syngenta Group Company. Tank mixtures: The applicable labeling for each product must be in the possession of the user at the time of application. Follow applicable use instructions, including application rates, precautions and restrictions of each product used in the tank mixture. Not all tank mix product formulations have been tested for compatibility or performance other than specifically listed by brand name. Always predetermine the compatibility of tank mixtures by mixing small proportional quantities in advance. Degree® is a registered trademark of Monsanto Technology LLC. Channel®, Channel® and the Arrow Design® and Seedsmanship At Work® are registered trademarks of Channel Bio, LLC. Services and products offered by Climate LLC are subject to the customer agreeing to our Terms of Service. Our services provide estimates or recommendations based on models. These do not guarantee results. Consult with your agronomist, commodity broker, or other industry professional before making financial, farming, or risk management decisions. More information at www.climate.com/legal/disclaimer. FieldView™ is a trademark of Climate LLC. Herculex® is a registered trademark of Dow AgroSciences LLC. Clearfield®, Copeo®, ILeVO®, LibertyLink logo® , LibertyLink®, Poncho®, Poncho®/Votivo® and Votivo® are trademarks of BASF Corporation. Respect the Refuge and Corn Design® and Respect the Refuge® are registered trademarks of National Corn Growers Association. Some of the product(s) discussed herein are restricted use pesticide(s) and may not be registered in all states. The distribution, sale, or use of an unregistered pesticide is a violation of federal and/or state law and is strictly prohibited. Check with your local dealer or product representative for the product registration status in your state. Absolute®, Acceleron®, Adament™, Admire®, Aeris®, Aliette®, Alion®, Allegiance®, Asgrow and the A Design®, Asgrow®, Autumn™, Axiom®, Balance®, Bayer, Bayer Cross, Baythroid®, BioRise®, Bollgard II®, Bollgard®, BUTEO™ start, Capreno®, ConnectIN™, Corn States Triangle Design®, Corvus®, Degree Xtra®, DEKALB and Design®, DEKALB®, Delaro®, Deltapine Select™, Deltapine®, DiFlexx®, Disease Shield®, DroughtGard®, DryTough™, Emesto®, Evergol®, EverGol®, FarmFlex®, Finish®, Flint®, Fontanelle Hybrids and Design®, Fontanelle Hybrids®, Gaucho®, Gem®, Ginstar®, Gold Country Seed®, Ground Breakers®, H Hubner and Design™, Harness®, Hubner Seed & Design®, Hubner Seed Your Trustworthy Seed Resource & Design®, Hubner Seed™, Huskie®, Jung Seed Genetics & Design®, Jung Seed Genetics™, Kruger Seeds™, Laudis® , Leaf Triangle Design®, Leverage®, Lewis Hybrids and Design®, Lewis Hybrids™ , Lewis Premium Grains & Design®, Luna Experience®, Luna Privilege®, Luna Sensation®, Luna Tranquility®, Luna® Flex, Luna® Pro Fungicide, Luxxur®, MILK MAXX SILAGE RESEARCH and Design®, Minuet™, Movento®, Movento® HL, Nortron®, Oberon®, Olympus®, Poncho®, Preceon™, Proline®, Propulse®, Prosaro®, Prosper®, Provost®, Raxil®, REA Hybrids and Design™, Rea Hybrids™ , Respect the Refuge and Cotton Design®, RIB Complete and Design®, RIB Complete®, Ricestar®, Rimfire®, Roundup PowerMAX®, Roundup Ready 2 Technology and Design®, Roundup Ready 2 Xtend®, Roundup Ready 2 Yield®, Roundup Ready®, Roundup Technology®, Roundup WeatherMAX and Design®, Roundup WeatherMAX®, Roundup®, RT 3 Powered by Roundup Technology and Design®, RT 3®, Scala®, Serenade®, Serenade® SOIL fungicide, SilageSmart & Design®, SilageSmart®, Sivanto®, SmartStax®, Specialty and Design®, Specialty Hybrids™, SR and Design®, Stance®, Stewart and Design™, Stewart Seeds™, Stone Seed & Design™, Stone Seed™, Stratego®, ThryvOn™, Trecepta®, Trilex®, TripleFLEX®, TriVolt™, TruFlex™, VaporGrip®, Varro®, Velum®, Vistive®, VT Double PRO®, VT Triple PRO®, VT4PRO™, VT4PRO™ , Warrant®, WestBred and Design®, WestBred®, Wolverine®, XtendFlex®, XtendiMax® and YieldGard VT PRO® are trademarks of Bayer Group. All other trademarks are the property of their respective owners. For additional product information call toll-free 1-866-99-BAYER (1-866-992-2937) or visit our website at www.BayerCropScience.us. Bayer CropScience LP, 800 North Lindbergh Boulevard, St. Louis, MO 63167. ©2024 Bayer Group. All rights reserved.

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